Main Reasons of Anemia {Lack of Hemoglobin}

‘’Reasons of Anemia’’

Ultimately, only three causes of anemia exist:

Blood loss,

Increased destruction of RBCs (hemolysis), and

Decreased making of RBCs.

Each of these reasons includes a number of disorders that need specific and appropriate therapy.:                                              ‘’Reasons of Anemia’’

Vitamin deficiency Anemia.

In addition to iron, body requirements foliate and vitamin B-12 to produce enough healthy red blood cells. A diet lacking in these and other key nutrients can reason decreased red blood cell production.

Certain people may consume enough B-12, but their bodies lack a substance called ‘Intrinsic factor’ vital for the proper absorption of the vitamin. This can lead to vitamin deficiency anemia, also recognized as pernicious anemia.  ‘’Reasons of Anemia’’

Iron deficiency anemia.

This is the most common kind of anemia worldwide.

Affected by a shortage of iron in body. Bone marrow needs iron to make hemoglobin. Without adequate iron, body can’t produce sufficient hemoglobin for red blood cells.

This kind of anemia occurs in many pregnant women.  ‘’Reasons of Anemia’’

It is also caused by blood loss, such as from heavy menstrual bleeding, an ulcer, cancer and regular usage of some pain killers, especially aspirin.

Anemia due to blood loss

It can be of rapid onset like in cases of trauma and bleeding or slow ongoing procedure like bleeding from the gut due to peptic ulcers or inflammatory bowel diseases like crohn’s disease                                  ‘’Reasons of Anemia’’

Anemia of chronic disease.

Certain long standing diseases like cancer, HIV/AIDS, rheumatoid arthritis, kidney disease, Crohn’s disease and other chronic inflammatory diseases, can interfere with the making of red blood cells.

Aplastic anemia

This rare, life-threatening anemia occurs when the bone marrow doesn’t create red blood cells                                           ‘’Reasons of Anemia’’

Reasons of aplastic anemia include infections, certain medicines, autoimmune diseases and exposure to toxic chemicals.

Anemia’s associated with bone marrow disease.

A variety of diseases, such as leukemia and myelofibrosis, can reason anemia by affecting blood production in the bone marrow. Some of these disorders can be life threatening

Hemolytic anemias.

This group of anemia’s develops when red blood cells are damaged faster than bone marrow can replace them. Certain blood diseases increase red blood cell destruction. A hemolytic anemia can be hereditary, or acquired later in life.‘’Reasons of Anemia’’

Sickle cell anemia

This inherited and occasionally serious condition is an inherited hemolytic anemia.

It’s caused by a defective form of hemoglobin that forces red blood cells to shoulder an abnormal crescent (sickle) shape. These irregular blood cells die prematurely, subsequent in a long term shortage of red blood cells.

Thalassemia

It is another kind of inherited anemia due to mutation in genes responsible for globin protein formation leading to abnormal globin protein in the hemoglobin molecule.

 ‘’Reasons of Anemia’’

It is of two kinds – Alpha Thalassemia and Beta Thalassemia with outcome varying from no indications to death in infancy depending on the subtype

Anemia’s due to various infections

Viral – Viral Hepatitis, infective mononucleosis, cytomegalovirus (CMV)

Bacterial – Clostridial infective (Tetanus), gram-negative bacterial septicemia

Protozoal – Malaria, leishmaniasis (Kala azar), toxoplasmosis

Anemia due to Drugs or chemicals

They commonly source the aplastic and hypo plastic group of disorders.

Medicines like Chloramphenicol (Antibiotic earlier used in Typhoid), sulfonamides or ant thyroid drugs can source bone marrow suppression and anemia

 ‘’Reasons of Anemia’’

Any human exposed to a adequate dose of inorganic arsenic, benzene, radiation, or the usual cancer chemotherapy drugs can grow bone marrow depression with anemia.

Main Reasons of Anemia {Lack of Hemoglobin}